Atlas · Plate IV · Physiology · 06
Nerve and muscle
The sympathetic system drives fight or flight, raising heart rate and blood pressure, while the parasympathetic system handles rest and digest. Receptor types explain many drug effects: alpha-1 narrows vessels, beta-1 speeds and strengthens the heart, and beta-2 opens the airways. Local anesthetics block sodium channels, so small pain fibers go numb before touch, pressure and motor fibers.
High-yield facts · 6
- The sympathetic system is "fight or flight" (raises heart rate and BP); the parasympathetic is "rest and digest."S49
- Acetylcholine is the main parasympathetic neurotransmitter; norepinephrine is the main sympathetic one.S49
- Alpha-1 receptors constrict vessels; beta-1 receptors raise heart rate and force; beta-2 receptors dilate bronchi.S51
- Local anesthetics block voltage-gated sodium channels, stopping nerve impulse conduction.S14
- Small myelinated fibers are blocked before large ones: pain goes first, then temperature, touch, pressure, motor.S14
- Nodes of Ranvier speed conduction in myelinated nerves; about 8-10 mm of nerve (three nodes) must be bathed in anesthetic to block it.T1
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